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Thyroid Radioactive Iodine Ablation

gt;gt; for some conditions of the thyroid, THERE ARE REALLY TWO APPROACHES. YOU CAN SURGICALLY REMOVE THE ENTIRE THYROID GLAND, OR YOU CAN TREAT IT WITH RADIOACTIVE IODINE TO BASICALLY ABLATE THE THYROID TISSUE. THE THYROID IS UNIQUE IN THE BODY IN THAT IT TAKES UP.

Iodine or iodinerelated compounds specifically. gt;gt; SO RADIOACTIVE IODINE ABLATION, OR RADIOACTIVE IODINE TREATMENT, TAKES ADVANTAGE OF A NORMAL PROCESS WHERE THE THYROID CELLS, WHETHER THEY’RE THYROID CANCER OR NORMAL THYROID CELLS OR EVEN GRAVES’ CELLS,.

Usually take iodine to make thyroid hormone, BUT THIS TIME WE GIVE THE PATIENT RADIOACTIVE IODINE TO DESTROY THE THYROID GLAND. gt;gt; IN A PATIENT WITH GRAVES’ DISEASE, RADIOACTIVE IODINE TREATMENT IS MORE OF A DEFINITIVE THERAPY FOR THAT PATIENT, AND AT A LOWER DOSE CAN BE.

Used in this manner, to destroy the thyroid cells FROM PRODUCING THE EXCESS THYROID HORMONE. gt;gt; WE’RE TRYING TO GET RID OF THE ENTIRE THYROID GLAND. SO IF YOU USE RADIOACTIVE IODINE, YOU’RE TRYING TO GIVE A BIG ENOUGH DOSE THAT YOU CAUSE SCARRING DOWN UNDER THE THYROID GLAND SO YOU GET RID.

Of the graves’ disease. FOR RADIOACTIVE IODINE ABLATION, OFTENTIMES WE RESTRICT IT TO CHILDREN THAT ARE OVER AGE 5 AND MANY TIMES ACTUALLY OVER AGE 10, IF WE’RE GOING TO CONSIDER THEM FOR THAT TYPE OF THERAPY, COMPARED TO EITHER STAYING ON MEDICAL THERAPY.

Radioactive Iodine Ablation for Thyroid Cancer Pediatric Thyroid Center at CHOP 6 of 9

gt;gt; in patients with thyroid cancer, RADIOACTIVE IODINE IS ACTUALLY USED AS THE SECOND PART OF THEIR THYROID CANCER TREATMENT. gt;gt; THE THYROID IS UNIQUE IN THE BODY IN THAT IT TAKES UP IODINE OR IODINERELATED COMPOUNDS, SPECIFICALLY. gt;gt; SO RADIOACTIVE IODINE ABLATION,.

Or radioactive iodine treatment, TAKES ADVANTAGE OF A NORMAL PROCESS WHERE THE THYROID CELLS, WHETHER THEY’RE THYROID CANCER OR NORMAL THYROID CELLS OR EVEN GRAVES’ CELLS, USUALLY TAKE IODINE TO MAKE THYROID HORMONE, BUT THIS TIME WE GIVE THE PATIENT RADIOACTIVE IODINE.

gt;gt; radioactive iodine can then bump off, BASICALLY, THE THYROID CELLS, PARTICULARLY THYROID CANCER CELLS. gt;gt; IT’S THOSE RESIDUAL CELLS THAT EITHER STILL CAN HARBOR THE THYROID CANCER OR CAN BE A REASON FOR THYROID CANCER TO RETURN.

gt;gt; following surgery for thyroid cancer, A PATIENT IS SEEN BACK IN THE ENDOCRINE OFFICE ABOUT TWO TO THREE WEEKS LATER. gt;gt; DURING THIS TIME, THEY RECEIVE ALL THE INFORMATION AND GUIDELINES THEY NEED TO ANTICIPATE THEIR RADIOACTIVE IODINE TREATMENT.

The actual radioactive iodine treatment takes place ABOUT SIX WEEKS AFTER SURGERY, OR ABOUT THREE TO FOUR WEEKS AFTER THEY’RE SEEN FOR THEIR FOLLOWUP VISIT. WHEN THE PATIENT COMES IN AND RECEIVES A VERY LOW DOSE OF RADIOACTIVE IODINE. gt;gt; WE GIVE THEM A SMALL DOSE TO TRY TO FIGURE OUT HOW.

Much tissue is left. gt;gt; THE FOLLOWING DAY, THEY COME BACK AND HAVE A WHOLE BODY SCAN. THAT SCAN GIVES US A SENSE OF HOW MUCH RADIOACTIVE IODINE WAS TAKEN UP IN THE BODY AS WELL AS WHERE WAS IT TAKEN UP IN THE BODY.

The patient then comes in that third consecutive day, RECEIVES THEIR ACTUAL RADIOACTIVE IODINE TREATMENT AT A MUCH HIGHER DOSE THAN THEY RECEIVED TWO DAYS PRIOR. THE FOLLOWING WEEK, THE PATIENT COMES BACK FOR WHAT WE CALL A POSTTREATMENT WHOLE BODY SCAN. THIS WHOLE BODY SCAN IS CRUCIAL TO SERVE.

As a baseline to understand where exactly the patient DOES HAVE DISEASE. gt;gt; THE ADVANTAGE TO DOING THAT IS IF YOU CAN GET RID OF ALL THE CELLS, THEN YOU CAN USE A PROTEIN THAT THOSE CELLS MAKE AS A MARKER OF CANCER. AND THAT PROTEIN IS CALLED THYROGLOBULIN.

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